Personalized clinical trial list

My friend received a life-changing diagnosis, and we both knew clinical trials would eventually be her best chance at sustained cancer remission.  As a UCSF, Stanford, and MD Anderson trained medical professional, I searched ClinicalTrials.gov for hours, discovering that this wonderful database still lacks consistent information about each trial's experimental or novel therapy's mechanism of action and specific cancer types included.  Many trials include this information, making simple searches for words like "lung" or "KRAS" effective.  But, some trials do NOT include this information, despite being large, cutting edge trials with exciting new drugs and sometimes even impressive preliminary results.

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Example (from a large, international cancer clinical trial with 39 study locations):
A First-in-human Study of XX-XXX in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors
Brief Summary: This is a Phase 1a/b, multicenter, open-label, first-in-human, dose escalation, expansion and extension study to evaluate the safety, tolerability, and DLTs to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) and preliminary efficacy of XX-XXX (study drug) in participants with locally advanced unresectable or metastatic solid tumors.

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This clinical trial title and description lacks the following: mechanism of action or target of the drug and types of tumors thought to be treatable by this drug.  This large, actively recruiting clinical trial therefore would not show up in a search for clinical trials for stomach (gastric), pancreatic, colon, or liver (hepatic) cancer, yet it turns out this therapy targets a receptor that is often found on all of those types of cancer, plus more.  A patient or oncologist who is short on time would not see this trial with a typical search using the current ClinicalTrials.gov website, yet this is one of the newest and more promising therapies offered for these types of cancer.

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Notably, positive results from this clinical trial were published in Nature Medicine in June 2025, but the official ClinicalTrials.gov website still shows results as "none posted."

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CancerTrialMatch aims to better summarize ClinicalTrials.gov data in real-time, with more complete information regarding the cancer trial drugs and types of cancer treated.  We will also aim to use AI to summarize relevant news announcements and preliminary results, to give patients and clinicians as much as information as possible when selecting which clinical trials to consider.